MARKERS OF NEUROVISULATION IN MIGRAINE DIAGNOSTICS
DOI:
https://doi.org/10.21802/2304-7437-2019-5(57)-108-113Keywords:
migraine, neuroimaging, biomarkers, voxel morphometry, functional magnetic resonance tomography (fMRT)Abstract
In clinical medicine, the diagnosis of migraine is based on anamnesis and symptoms, and instrumental diagnostic methods are considered non-informative. Numerous studies of the brain, during headaches and between them, have made a significant contribution to understanding the pathophysiology of migraines. Structural and functional changes in the migraine brain are revealed by advanced magnetic resonance imaging techniques, and attempts to detect the visualization markers of this disease progressively increase. This overview article aims to summarize the results of recent studies that reflect achievements in understanding the pathophysiology of migraine, as well as the possibility of using neuroimaging techniques in diagnosing migraines.
References
Aguila M.E.R., Lagopoulos J., Leaver A.M., Rebbeck T., Hübscher M., Brennan P.C., & Refshauge, K.M. (2015). Elevated levels of GABA+ in migraine detected using 1H-MRS. NMR in Biomedicine, 28(7), 890-897.
Bilgiç B., Kocaman G., Arslan A.B., Noyan H., Sherifov R., Alkan A., ... & Baykan B. (2016). Volumetric differences suggest involvement of cere-bellum and brainstem in chronic migraine. Cephalalgia, 36(4), 301-308.
Bose P., Karsan N., Zelaya F., & Goadsby P. (2017). 1557 Alterations in cerebral blood flow during the postdrome phase of a migraine attack captured with arterial spin labelled (asl) mri.
Burstein R., Noseda R., Borsook D. Migraine: multiple processes, complex pathophysiology. Journal of Neuroscience. 2015;35(17): 6619-6629.
Burstein R., Jakubowski M., Garcia-Nicas E., Kainz V., Bajwa Z., Hargreaves R., ... & Borsook D. (2010). Thalamic sensitization transforms localized pain into widespread allodynia. Annals of neurology, 68(1), 81-91.
DaSilva A.F., Nascimento T.D., Love T., DosSantos M.F., Martikainen I.K., Cummiford C.M., ... & Hall T. (2014). 3D-neuronavigation in vivo through a patient's brain during a spontaneous migraine headache. Journal of visualized experiments: JoVE, (88).
Nyholt D.R., Borsook D., & Griffiths L.R. (2017). Migrainomics—identifying brain and genetic markers of migraine. Nature Reviews Neurol-ogy, 13(12), 725.
Palm-Meinders I.H., Koppen H., Terwindt G.M., Launer L.J., Konishi J., Moonen J.M., ... & van Buchem M.A. (2012). Structural brain changes in migraine. Jama, 308(18), 1889-1896.
Russo A., Silvestro M., Tessitore A., & Tedeschi, G. (2018). Advances in migraine neuroimaging and clinical utility: from the MRI to the bed-side. Expert review of neurotherapeutics, 18(7), 533-544.
Vos T., Abajobir A.A., Abate K.H., Abbafati C., Abbas K.M., Abd-Allah F., ... & Aboyans V. (2017). Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Dis-ease Study 2016. The Lancet, 390(10100), 1211-1259.