AUTOPHAGY - CLINICAL PERSPECTIVES

Authors

  • С. М. Геник Ivano-Frankivsk National Medical University
  • О. І. Дєльцова Ivano-Frankivsk National Medical University

Keywords:

аutophagy, aging, cancer, neurodegeneration’s diseases.

Abstract

The review is devoted to interpretation results of modern investigations of the process of the autophagy and it takes part in development, proceeding, implications of this theoretical dates for future pathways of prevention aging, search of new methods of the therapy of cancer and different diseases including neurodegenerative and cardiovascular diseases. In review was presented the results of regulation of the aging process by autophagy. It was bring the results of integrity of the autophagosomal-lysosomal network appears to be critical in the progression of aging. There was idea about the role of the endoplasmic reticulum stress and autophagy as target for cancer therapy. It was discussed the potential of pro- as well as anti-autophagic signaling pathways as targets for future cancer therapy. It was informed about the importance of neuronal survival factor through chaperone-mediated autophagy which links the deregulation of this pathway to Parkinson’s disease. It was demonstrative the significance of autophagy in cellular health and disease of organs of alimentary system, cardio-vascular system, and cellular autophagy: surrender, avoidance and subversion by microorganisms.

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Published

2019-09-24

How to Cite

Геник, С. М., & Дєльцова, О. І. (2019). AUTOPHAGY - CLINICAL PERSPECTIVES. PRECARPATHIAN BULLETIN OF THE SHEVCHENKO SCIENTIFIC SOCIETY Pulse, (4(12), 59-69. Retrieved from https://pvntsh.nung.edu.ua/index.php/pulse/article/view/895

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