DYNAMICS AND DOSE DEPENDENCES OF IRON DEVIATION IN THE INFECTED ANIMALS BLOOD
Keywords:
-radiation, dose, power, iron content in blood of ratsAbstract
The variations of iron content in the rats Wistar’s blood after their one-time irradiation by γ-quanta from 60Со source at dose of 0.1 Gy/min power have been investigated with 0.2; 0.5; 1.0; 3.0; 5,0; 7.0 and 9.0 Gy doses. The research has been conducted at 0.5; 1, 2, 4, 6, 8, 10, 15, 20, 30, 45, 60, 90, 120 days after irradiation. The work purpose was to study the effects of both small and high doses of ionizing radiation on the dynamics of the iron amount in the blood of rats for a long time. It was found that under the influence of γ-radiation at doses of 0.2, 0.5 and 1.0 Gy in 2 days, iron content in rat blood has been changed slightly. At 2 days after radiation in higher doses, the iron concentration got a minimum value and it was directly proportional to the dose. In subsequent terms, the iron level of the blood was closer to the original values. The change in the concentration of the trace element under the influence of irradiation at doses of 3-9 Gy, had a positive balance of nature after 8-20 days and reached the maximum values at 8-10 days, and in groups of animals irradiated at a dose of 9.0 Gy, the increase of iron in the blood has been continued until the 15th day. By the end of the experiment, the iron content in the blood showed normalization tendency. The reducing the iron content in the rat blood after 0.5, 1 and 2 days after the radiation action was directly proportional to the dose, and its accumulation in the following terms (8, 10 and 15 days) had a reversible dependence, iron content in the blood through 8 and 10 days was the same in all groups. The rate of reduction of iron content in the blood of rats in 12 hours and the rate of its accumulation in 4 and 6 days were directly proportional to the dose value. The oscilation of this index in the groups of animals irradiated at doses of 0.2, 0.5 and 1.0 Gy were small. Reducing the iron content in rats’ blood by 1 Gy was directly proportional to the dose value at 2 days after exposure. The relative increase of the value was observed in these animals at 6-10 days after exposure. The indicator did not depend on the dose in the range of 1.0-9.0 Gy, but only on the time after exposure, except for the 8th and 10th day.
The obtained results of the dynamics of iron content in the process of the radiation effect can be used in the development of new methods of complex treatment of radiation sickness, as well as in the use of X-therapy.
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