BREAST STEM CELLS AND THEIR PARTICIPATION IN CARCINOGENESIS
Keywords:
breast, stem cells, carcinogenesis.Abstract
The results of contemporary researches of breast stem cells are considered in the article. Cogent arguments for the presence of three types of progenitor cells – for myoepithelial cells, epithelium of ducts and epithelial cells of mammary gland are given. Their role in the origin of breast cancer is discussed.
References
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9. Brisken C. Stem cells and the stem cell niche in the breast: an integrated hormonal and developmental perspective / C.Brisken, S.Duss // Stem Cell Rev. – 2007. – Vol. 3(2). – P. 147-156.
10. Bruno R.D. Functional characterization of stem cell activity in the mouse mammary gland / R.D.Bruno, G.H.Smith // Stem Cell. – 2011. – Vol. 7(2). – P. 238-247
11. Cancer stem cell markers in breast neoplasias: their relevance and distri-bution in distinct molecular subtypes / F.Schmitt, S.Ricardo, A.F.Viera [et al.] // Virchows Arch. – 2012. – Vol. 460(6). – P. 545-553.
12. CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells / K.E.Sleeman, H.Kendrick, A.Ashworth [et al.] // Breast Cancer Res. – 2006. – Vol. 8(1). – P. R7.
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14. Clayton H. Growth and differentiation of progenitore/stem cells derived from the human mammary gland / H.Clayton, J.Titley, M.Vivanco // Exp. Cell Res. – 2004. – Vol.297(2). – P. 444-460.
15. Chepko G. Ultrastructure of the putative stem cell niche in rat mammary epithelium / G.Chepko, R.B.Dickson // Tissue Cell. – 2003. – Vol. 35(2). – P. 83-93.
16. Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept / W.Boker, R.Moll, C.Poremba [et al.] // Lab. Invest. – 2002. – Vol. 82(6). – P. 737-744.
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20. Distinct stem cells contribute to mammary gland development and main-tenance / A.Van Keymeulen, A.S.Rosha, M.Ontsset [et al.] // Nature. – 2011. – Vol. 479(7372). – P. 189-193.
21. Epithelial progenitors in the normal human mammary gland / J.Stingl, A.Raouf, J.T.Emerman [et al.] // J. Mammary Gland Biol. Neoplasia. – 2005. – Vol. 10(1). – P. 49-59.
22. Farmie G. Mammary stem cells and breast cancer – role of notch signal-ling / G.Farmie, R.B.Clarke // Stem Cell Rev. – 2007. – Vol. 3(2). – P. 169-175.
23. Generation of a functional mammary gland from a single stem cell / M.Shakleton, F.Valliant, K.J.Simpson [et al.] // Nature. – 2006. – Vol. 439(7072). – P. 84-88.
24. Glazer R. Musashi 1: an RBP with vesatile functions in normal and can-cer stem cells / R.Glazer, D.T.Vo, L.O.Penalva // Front. Diosci. – 2012. – Vol.17. – P. 54-64.
25. Guest I. Preparation of epithelial and mesenchimal stem cells from mur-ine mammary gland / I.Guest, Z.Ilic, J.Ma // Curr. Protoc. Toxicol. – 2011. – Chapter 22: Unit 22. – Р. 3.
26. Gupta S. Targeting the Hedgehog pathway in cancer / S.Gupta, N.Take-be, P.Lorusso // Ther. Adv. Med. Oncol. – 2010. – Vol.2(4). – P. 237-250.
27. Holland M.S. The cellular perspective on mammary gland development stem/progenitor cells and beyond / M.S.Holland, R.E.Holland // J. Dairy Sci. – 2005. – Vol.88. Sup.1. – P. E1-8.
28. Joshi P.A. Active allies: hormone, stem cells and the niche in adult mammopoiesis / P.A.Joshi, M.A.Di Grappa, R.Knokha // Trends Endocri-nol. metab. – 2012. – Vol.23(6). – P. 299-309.
29. Joshi P.A. Mammarystem cell comedrum: is it unipotent or multipotent / P.A.Joshi, R.Knokha // Вreast Cancer Res. – 2012. – Vol.14(2). – P. 305.
30. Kaimala S. Mammary gland stem cells: more puzzles than explanation / S.Kaimala, S.Bisana, S.Kimar // J. Biosci. – 2012. – Vol.37(2). – P. 349-358.
31. Keller P.J. Stem cells maintance of the mammary gland: it takes two / P.J. Keller, L.M. Arendt, C. Kuperwasse // CellStem Cell. – 2011. – Vol.9(6). – P. 496-497.
32. La Barge M.A. Of microenvironments and mammary stem cells / M.A.La Barge, O.W.Petersen, M.J.Bissel // Stem Cell Rev. – 2007. – Vol.3(2). – P.137-146.
33. Maintenance of cell type diversification in the human breast /A.J.Fridriksdottir, R.Villadsen, T.Gudjonsson [et al.] // J. Mammary Gland Biol. Neoplasia. – 2005. – Vol. 10(1). – P. 61-74.
34. Mammary gland development: Role of basal myoepithelial cells / M.M. Faraldo, I. Taddei-De Hosseraye, J. Teuliere [et al.] // J. Soc. Biol. – 2006. – Vol. 2000(2). – P. 193-198.
35. Matulka L.A. Parity-induced mammary epithelial cells are multipotent and express cell surface markers assosiated with stem cells / L.A.Matulka, A.A.Triplet, K.U.Wagner // Dev. Biol. – 2007. – Vol. 303(1). – P. 29-44.
36. Molyneux G. Mammary stem cells and breast cancer / G.Molyneux, J.Re-gan, M.J.Smally // Cell Mol. Life Sci. – 2007. – Vol.64(24). – P. 3248-3260.
37. Obr A.T. The biology of progesterone receptor in the normal mammary gland and in breast cancer / A.T.Obr, D.P.Edwards // Mol. Cell Endocrinol. – 2012. – Vol. 357(1-2). – P. 4-17.
38. Oliveira L.R. Stem cells in human breast cancer / L.R.Oliveira, S.S.Jeffrey, A.Ribeiro-Silva // Histol. Histopathol. – 2010. – Vol. 25(3). – P. 371-385.
39. Phenotypic and functional characterization of human mammary stem/progenitor cells in long term culture / D.Dey, M.Saxena, A.N.Paranijape [et al.] // PLoS One. – 2009. – Vol. 4(4). – P. e5329.
40. Polyak K. Do myoepithelial hold the key for breast tumor progression? / K.Polyak, M.Hu // J. Mammary Gland Biol. Neoplasia. – 2005. – Vol. 10(3). – P.231-247.
41. Primary breast myoepithelial cells exert an invasion-suppressor effect on breast cancer cells via paracrine down-regulation of MMP expression in fi-broblasts and tumor cells / J.L. Jones, J.A. Shaw, J.H. Pringle [et al.] // J. Pathol. – 2003. – Vol. 201(4). – P. 562-572.
42. RANK ligand mediates progestin-induced mammary epithelial prolifera-tion and carcinogenesis / E. Gonzalez-Suarez, A.P. Jacob, J. Jones [et al.] // Nature. – 2010. – Vol. 468(7320). – P. 103-107.
43. Reedijk M. Notch signaling and breast cancer / M.Reedijk // Adv. Exp. Med. Biol. – 2012. – Vol. 427. – P. 241-247.
44. Regan J. Prospective isolation and functional analysis of stem and differ-entiated cells from the mouse mammary gland / J.Regan, M.Smalley // Stem Cell Rev. – 2007. – Vol. 3(2). – P. 124-136.
45. Resident macrophagus influence stem cell in the mammary gland / D.E.Gyorki, M.L.Asselin-Labat, N. van Rooigen [et al.] // Breast Cancer Res. – 2009. – Vol. 11(4). – P. R62.
46. Shared signaling pathways in normal and breast cancer stem cells / G.K.Malhotra, X.Zhao, H.Band [et al.] // J. Carcinog. – 2011. – Vol. 10. – P. 38.
47. Smith G.H. Mammary epithelial stem cells / G.H.Smith, G.Chepko // Mi-crosc. Res. Tech. – 2001. – Vol. 15(2). – P. 190-203.
48. Smith G.H. Mammary stem cells come of age, prospectively / G.H.Smith // Trends Mol. Med. – 2006. – Vol. 12(7). – P. 287-289.
49. Stem cells in normal mammary gland and breast cancer / J.Luo, X.Jin, T.Ma [et al.] // Am. J. Med. Sci. – 2010. – Vol. 339(4). – P. 366-370.
50. Tanos T. What signals operate in the mammary? / T.Tanos, C.Brisken // Breast Dis. – 2008. – Vol. 29. – P. 69-82.
51. Targening cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways / N.Takebe, P.J.Harris, R.Q.Warren [et al.] // Nat. Rev. Clin. On-col. – 2011. – Vol. 8(2). – P. 97-106.
52. Targeted activation of beta-catenin signaling in basal mammary epithelial cell effects mammary development and leads to hyperplasia / J.Teuliere, M.M.Faraldo, M.A.Deugnier [et al.] // Development. – 2005. – Vol.132(2). – P. 267-277.
53. The emerging picture of the mouse mammary stem cell / F.Vaillant, M.L.Asselin-Labat, M.Shackleton [et al.] // Stem Cell Rev. – 2007. – Vol. 3(2). – P. 114-123.
54. The mouse mammary microenvironment redicts mesoderm-derived bone marrow cells to a mammary epithelial progenitor cell fate / C.A.Boulander, R.D.Bruno, M.Rosu-Myles [et al.] // Stem Cell. – 2012. – Vol.21(6). – P. 948-954.
55. The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of virgin mouse / R.Fernandez-Valdivia, A.Mukherjee, Y.Ying [et al] // Dev. Biol. – 2009. – Vol.328(1). – P. 127-139.
56. Villadsen R. In search of a stem cell hierarchy in the human breast and its relevance to breast cancer evolution / APMIS. – 2005. – Vol.113(11-12). – P. 903-921.
57. Visvader J.E. Murine mammary epithelial stem cells: discovery, function, and current status / J.E.Visvader, G.H.Smith // Cold Sprinh. Harb. Perspect. Biol. – 2011. – Vol. 3(2). – P.55-58.
2. A protocol to quantity mammary early common progenitors from long-term mammosphere culture / F.Bachelard-Cascales, M.Chapellier, E.Delay [et al.] // Curr. Protoc. Stem Cell Biol. – 2012. – Chapter 1: Unit 1E. – Р. 7.
3. Bandypadhyay A. Stem/Progenitor cells in murine mammary gland: isola-tion and functional characterization / A.Bandypadhyay, Q.Dong, L.Z.Sun // Methods Mol. Biol. – 2012. – Vol.879. – P. 179-193.
4. Barsky S.H. Myoepithelial cells: autocrine and paracrine supressors of breast cancer progression / S.H.Barsky, N.J.Karlin // J. Mammary Gland Biol. Neoplasia. – 2005. – Vol.10(3). – P. 249-260.
5. Blanpain C. Epithelial stem cells: turning over new leanes / C.Blanpain, V.Horsley, E.Fuch // Cell. – 2007. – Vol. 128(3). – P. 445-458.
6. Boker W. Anatomy of the breast / W.Boker, D.Hungermann, T.Decker // Pathologe. – 2009. – Vol. 30(1). – P. 6-12.
7. Both B.W. Alveolar progenitor cells develop in mouse mammary glands independent of pregnancy and lactation / B.W.Both, C.A.Boulanger, G.H.Smith // J. Cell Physiol. –2006. – Vol. 212(3). – P. 729-736.
8. Boulander C.A. Reprogramming cell fates in the mammary microenviron-ment / C.A.Boulander, G.H.Smith // Cell Cycle. – 2009. – Vol. 8(8). – P. 1127-1132.
9. Brisken C. Stem cells and the stem cell niche in the breast: an integrated hormonal and developmental perspective / C.Brisken, S.Duss // Stem Cell Rev. – 2007. – Vol. 3(2). – P. 147-156.
10. Bruno R.D. Functional characterization of stem cell activity in the mouse mammary gland / R.D.Bruno, G.H.Smith // Stem Cell. – 2011. – Vol. 7(2). – P. 238-247
11. Cancer stem cell markers in breast neoplasias: their relevance and distri-bution in distinct molecular subtypes / F.Schmitt, S.Ricardo, A.F.Viera [et al.] // Virchows Arch. – 2012. – Vol. 460(6). – P. 545-553.
12. CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells / K.E.Sleeman, H.Kendrick, A.Ashworth [et al.] // Breast Cancer Res. – 2006. – Vol. 8(1). – P. R7.
13. Clarke C. Myoepithelial cells: pathology, cell separation and markers of myoepithelial differentiation / C.Clarke, J.Sandle, S.R.Lakhani // J.Mammary Gland Biol. Neoplasia. – 2005. – Vol.10(3). – P. 273-280.
14. Clayton H. Growth and differentiation of progenitore/stem cells derived from the human mammary gland / H.Clayton, J.Titley, M.Vivanco // Exp. Cell Res. – 2004. – Vol.297(2). – P. 444-460.
15. Chepko G. Ultrastructure of the putative stem cell niche in rat mammary epithelium / G.Chepko, R.B.Dickson // Tissue Cell. – 2003. – Vol. 35(2). – P. 83-93.
16. Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept / W.Boker, R.Moll, C.Poremba [et al.] // Lab. Invest. – 2002. – Vol. 82(6). – P. 737-744.
17. Cremers N. Loss of CD24 expression promotes ductal branching in the murine mammary gland / N.Cremers, M.A.Deugnier, J.Sleeman // Cell Mol. Life Sci. – 2010. – Vol. 67(13). – P. 2311-2322.
18. Deciphering the mammary epithelial cell hierarchy / J.Stingl, A.Raouf, P.Eirew [et al.] // Cell Cycle. – 2006. – 2006. – Vol. 5(14). – P. 1519-1522.
19. Delineating the epithelial ierarchi in the mouse mammary gland / M.L.Asselin-Labat, F.Vaillant, M.Shalkton [et al.] // Cold Spring Harb. Symp. Quant Biol. – 2008. – Vol. 73. – P. 469-478.
20. Distinct stem cells contribute to mammary gland development and main-tenance / A.Van Keymeulen, A.S.Rosha, M.Ontsset [et al.] // Nature. – 2011. – Vol. 479(7372). – P. 189-193.
21. Epithelial progenitors in the normal human mammary gland / J.Stingl, A.Raouf, J.T.Emerman [et al.] // J. Mammary Gland Biol. Neoplasia. – 2005. – Vol. 10(1). – P. 49-59.
22. Farmie G. Mammary stem cells and breast cancer – role of notch signal-ling / G.Farmie, R.B.Clarke // Stem Cell Rev. – 2007. – Vol. 3(2). – P. 169-175.
23. Generation of a functional mammary gland from a single stem cell / M.Shakleton, F.Valliant, K.J.Simpson [et al.] // Nature. – 2006. – Vol. 439(7072). – P. 84-88.
24. Glazer R. Musashi 1: an RBP with vesatile functions in normal and can-cer stem cells / R.Glazer, D.T.Vo, L.O.Penalva // Front. Diosci. – 2012. – Vol.17. – P. 54-64.
25. Guest I. Preparation of epithelial and mesenchimal stem cells from mur-ine mammary gland / I.Guest, Z.Ilic, J.Ma // Curr. Protoc. Toxicol. – 2011. – Chapter 22: Unit 22. – Р. 3.
26. Gupta S. Targeting the Hedgehog pathway in cancer / S.Gupta, N.Take-be, P.Lorusso // Ther. Adv. Med. Oncol. – 2010. – Vol.2(4). – P. 237-250.
27. Holland M.S. The cellular perspective on mammary gland development stem/progenitor cells and beyond / M.S.Holland, R.E.Holland // J. Dairy Sci. – 2005. – Vol.88. Sup.1. – P. E1-8.
28. Joshi P.A. Active allies: hormone, stem cells and the niche in adult mammopoiesis / P.A.Joshi, M.A.Di Grappa, R.Knokha // Trends Endocri-nol. metab. – 2012. – Vol.23(6). – P. 299-309.
29. Joshi P.A. Mammarystem cell comedrum: is it unipotent or multipotent / P.A.Joshi, R.Knokha // Вreast Cancer Res. – 2012. – Vol.14(2). – P. 305.
30. Kaimala S. Mammary gland stem cells: more puzzles than explanation / S.Kaimala, S.Bisana, S.Kimar // J. Biosci. – 2012. – Vol.37(2). – P. 349-358.
31. Keller P.J. Stem cells maintance of the mammary gland: it takes two / P.J. Keller, L.M. Arendt, C. Kuperwasse // CellStem Cell. – 2011. – Vol.9(6). – P. 496-497.
32. La Barge M.A. Of microenvironments and mammary stem cells / M.A.La Barge, O.W.Petersen, M.J.Bissel // Stem Cell Rev. – 2007. – Vol.3(2). – P.137-146.
33. Maintenance of cell type diversification in the human breast /A.J.Fridriksdottir, R.Villadsen, T.Gudjonsson [et al.] // J. Mammary Gland Biol. Neoplasia. – 2005. – Vol. 10(1). – P. 61-74.
34. Mammary gland development: Role of basal myoepithelial cells / M.M. Faraldo, I. Taddei-De Hosseraye, J. Teuliere [et al.] // J. Soc. Biol. – 2006. – Vol. 2000(2). – P. 193-198.
35. Matulka L.A. Parity-induced mammary epithelial cells are multipotent and express cell surface markers assosiated with stem cells / L.A.Matulka, A.A.Triplet, K.U.Wagner // Dev. Biol. – 2007. – Vol. 303(1). – P. 29-44.
36. Molyneux G. Mammary stem cells and breast cancer / G.Molyneux, J.Re-gan, M.J.Smally // Cell Mol. Life Sci. – 2007. – Vol.64(24). – P. 3248-3260.
37. Obr A.T. The biology of progesterone receptor in the normal mammary gland and in breast cancer / A.T.Obr, D.P.Edwards // Mol. Cell Endocrinol. – 2012. – Vol. 357(1-2). – P. 4-17.
38. Oliveira L.R. Stem cells in human breast cancer / L.R.Oliveira, S.S.Jeffrey, A.Ribeiro-Silva // Histol. Histopathol. – 2010. – Vol. 25(3). – P. 371-385.
39. Phenotypic and functional characterization of human mammary stem/progenitor cells in long term culture / D.Dey, M.Saxena, A.N.Paranijape [et al.] // PLoS One. – 2009. – Vol. 4(4). – P. e5329.
40. Polyak K. Do myoepithelial hold the key for breast tumor progression? / K.Polyak, M.Hu // J. Mammary Gland Biol. Neoplasia. – 2005. – Vol. 10(3). – P.231-247.
41. Primary breast myoepithelial cells exert an invasion-suppressor effect on breast cancer cells via paracrine down-regulation of MMP expression in fi-broblasts and tumor cells / J.L. Jones, J.A. Shaw, J.H. Pringle [et al.] // J. Pathol. – 2003. – Vol. 201(4). – P. 562-572.
42. RANK ligand mediates progestin-induced mammary epithelial prolifera-tion and carcinogenesis / E. Gonzalez-Suarez, A.P. Jacob, J. Jones [et al.] // Nature. – 2010. – Vol. 468(7320). – P. 103-107.
43. Reedijk M. Notch signaling and breast cancer / M.Reedijk // Adv. Exp. Med. Biol. – 2012. – Vol. 427. – P. 241-247.
44. Regan J. Prospective isolation and functional analysis of stem and differ-entiated cells from the mouse mammary gland / J.Regan, M.Smalley // Stem Cell Rev. – 2007. – Vol. 3(2). – P. 124-136.
45. Resident macrophagus influence stem cell in the mammary gland / D.E.Gyorki, M.L.Asselin-Labat, N. van Rooigen [et al.] // Breast Cancer Res. – 2009. – Vol. 11(4). – P. R62.
46. Shared signaling pathways in normal and breast cancer stem cells / G.K.Malhotra, X.Zhao, H.Band [et al.] // J. Carcinog. – 2011. – Vol. 10. – P. 38.
47. Smith G.H. Mammary epithelial stem cells / G.H.Smith, G.Chepko // Mi-crosc. Res. Tech. – 2001. – Vol. 15(2). – P. 190-203.
48. Smith G.H. Mammary stem cells come of age, prospectively / G.H.Smith // Trends Mol. Med. – 2006. – Vol. 12(7). – P. 287-289.
49. Stem cells in normal mammary gland and breast cancer / J.Luo, X.Jin, T.Ma [et al.] // Am. J. Med. Sci. – 2010. – Vol. 339(4). – P. 366-370.
50. Tanos T. What signals operate in the mammary? / T.Tanos, C.Brisken // Breast Dis. – 2008. – Vol. 29. – P. 69-82.
51. Targening cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways / N.Takebe, P.J.Harris, R.Q.Warren [et al.] // Nat. Rev. Clin. On-col. – 2011. – Vol. 8(2). – P. 97-106.
52. Targeted activation of beta-catenin signaling in basal mammary epithelial cell effects mammary development and leads to hyperplasia / J.Teuliere, M.M.Faraldo, M.A.Deugnier [et al.] // Development. – 2005. – Vol.132(2). – P. 267-277.
53. The emerging picture of the mouse mammary stem cell / F.Vaillant, M.L.Asselin-Labat, M.Shackleton [et al.] // Stem Cell Rev. – 2007. – Vol. 3(2). – P. 114-123.
54. The mouse mammary microenvironment redicts mesoderm-derived bone marrow cells to a mammary epithelial progenitor cell fate / C.A.Boulander, R.D.Bruno, M.Rosu-Myles [et al.] // Stem Cell. – 2012. – Vol.21(6). – P. 948-954.
55. The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of virgin mouse / R.Fernandez-Valdivia, A.Mukherjee, Y.Ying [et al] // Dev. Biol. – 2009. – Vol.328(1). – P. 127-139.
56. Villadsen R. In search of a stem cell hierarchy in the human breast and its relevance to breast cancer evolution / APMIS. – 2005. – Vol.113(11-12). – P. 903-921.
57. Visvader J.E. Murine mammary epithelial stem cells: discovery, function, and current status / J.E.Visvader, G.H.Smith // Cold Sprinh. Harb. Perspect. Biol. – 2011. – Vol. 3(2). – P.55-58.
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2019-09-19
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Чайковський, Ю. Б., Дєльцова, О. І., & Геращенко, С. Б. (2019). BREAST STEM CELLS AND THEIR PARTICIPATION IN CARCINOGENESIS. PRECARPATHIAN BULLETIN OF THE SHEVCHENKO SCIENTIFIC SOCIETY Pulse, (4(20), 18–26. Retrieved from https://pvntsh.nung.edu.ua/index.php/pulse/article/view/853
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ТЕОРЕТИЧНА МЕДИЦИНА
