STRUCTURAL FEATURES OF PITUITARY-GONADS REARRANGEMENTS DURING DIABETIC EXPERIMENT
Keywords:
diabetes, pituitary, gonads.Abstract
Scientific research is devoted to studying of morphological and functional organization of pituitary-gonads in type 1 diabetes. During the research, pituitary gland, testes, ovaries of 60 Wistar rats were used, 20 of which served as control, and 40-modeled streptozotocin-induced diabetes. The material were taken after 2 and 4 weeks after the experiment. Experimental diabetes causes acute aseptic destruction of gonads with phases characteristics (alteration, exudation and malnutrition) and takes place against the backdrop of diabetic microangiopathy. They traced the morphological features of inhibition of interstitial cells, reduced the number and volume of Leydig cells, hypoplasia and malnutrition of spermatogenic epithelium are observed: there is decrease in the quantity of spermatogonia – by 29.3%, spermatocytes of I and II orders – by 40.1%, spermatids – by 26.5% as compared to the controlled, which causes a reduction in level of spermatogenic epithelium (40,29±1,42) mm (p<0.01). Under these conditions, by the mechanism of feedback activation of hormonal activity of gonadotrophs of adenohypophysis takes place, it was manifested as described in their morphological changes, in addition: light gonadotrophs remind castration cells by the ultrastructural organization, their nuclear-cytoplasmic index and bulk density in SG increased. Among these functional overload of these cells eventually leads to their destructive changes.
References
2. Діагностика і лікування переддіабету в континуумі гіперглікемії: коли починається ризик розвитку цукрового діабету? / A.J. Garber [та ін.] // Ліки України. – Київ: ТОВ «Інформаційний центр Медпромінфо». – 2009. – №1. – C. 8-15.
3. Лучицький Є.В. Еректильна дисфункція у чоловіків, хворих на цукровий діабет / Є.В. Лучицький, О.В. Качура // Ендокринологія. – 2001. – Т.6. – №1. – C. 121-123.
4. Паньків В.І. Сучасна медична допомога хворим на цукровий діабет / В.І. Паньків // Практична ангiологія: видання для лiкаря-практика. – 2008. – №3. – C. 12-18.
5. Подольський В.В. Визначення медико-соціального впливу сучасних технологій ведення вагітних із цукровим діабетом на стан репродуктивного здоров’я жінок фертильного віку / В.В. Подольський, Т.В. Авраменко, Т.В. Коломійченко // Здоровье женщины: Всеукраинский научно-практический журнал. – 2009. – №4. – C. 112-114.
6. Baccetti B. Insulin-dependent diabetes in men is associated with hypotha-lamo-pituitary derangement and with impairment in semen quality / B. Bac-cetti, A. La Marca, P. Piomboni // Hum. Reprod. – 2002. – Vol.17, №10. – P. 2673-2677.
7. The effect of callosotomy on testicular steroidogenesis in hemiorchidec-tomized rats: a pituitary-independent regulatory mechanism / P. Bancze-rowski, Z. Csaba, V. Csernus, I. Gerendai // Brain Res Bull. – 2000. – Vol.53, № 2. – P.227-232.
8. Chabrolle C. Effects of high levels of glucose on the steroidogenesis and the expression of adiponectin receptors in rat ovarian cells / C. Chabrolle, E. Jeanpierre, L. Tosca // Reprod Biol Endocrinol. – 2008. – Vol.19. – P. 6-11.
9. Pituitary-testicular axis function, biological to immunological ratio and charge isoform distribution of pituitary LH in male rats with experimental diabetes / A. Olivares, J.P. Mйndez, M. Cбrdenas [et al.] // Gen. Comp. En-docrinol. – 2009. – Vol.161, №3. – P. 304-312.
10. Rabbani S.I. Inhibitory effect of glimepiride on nicotinamide-streptozotocin induced nuclear damages and sperm abnormality in diabetic Wistar rats / S.I. Rabbani, K. Devi, S. Khanam // Indian J. Exp. Biol. – 2009. – Vol.47, №10. – P. 804-810.
