PECTIN AS A UNIVERSAL REMEDY IN THE FIGHT AGAINST COLORECTAL CANCER
Keywords:
pectin, colon cancer, treatment, chemotherapy.Abstract
Colon cancer is one of the most common cancer globally. It occupy the fourth place in the structure of total cancer incidence. The basic treatment for colon cancer is surgery combined with chemotherapy or radiotherapy. Usually chemotherapy is provided by injection route. Alternative to the usual chemotherapy might be oral intake of chemotherapeutic agents. In this way can be achieved the reduce of drug dose, systemic side effects and increased. Pectin can be used as colon-specific drug delivery agent, because colonic microflora can selectively digest it. So this leads to the prevention of drug release in the upper gastrointestinal tract. Pectin can be considered not only as drug carrier but also as therapeutic agent for use in the prevention and fight against colon cancer.
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2. Colonic health: fermentation and short chain fatty acids/ J.M. Wong, R. de Souza, C.W. Kendall et al. // J Clin Gastroenterol. – 2006. – Vol.40. –
P. 235-243.
3. Colorectal cancer: a multidisciplinary approach / R.S. Midgley, A. Merrie, D.J. Kerr et al. // Clinical gastroenterology and hepatology. – 2005. –
Vol.60. – P. 421-430.
4. Comparison of the amount of pectin in the human terminal ileum with the amount of orally administered pectin / D. Saito, S. Nakaji, S. Fukuda et al. // Nutrition. – 2005. – Vol. 21. – P. 914-919.
5. Development of enteric-coated calcium pectinate microspheres intended for colonic drug delivery / F. Maestrelli, M. Cirri, G. Corti et al. // Eur J
Pharm Biopharm. – 2008. – Vol. 69. – P. 508-518.
6. Efficacy of oral anticancer agents for colorectal cancer / J. Sakamoto, K. Oba, T. Matsui et al.] // Dis Colon Rectum. – 2006. – Vol.49. – P. 82-91.
7. Glinsky V.V. Modified citrus pectin anti-metastatic properties: one bullet, multiple targets / V.V. Glinsky, A. Raz // Carbohydr Res. – 2009. –
Vol.344. – P. 1788-1791.
8. In situ gelling xyloglucan/pectin formulations for oral sustained drug delivery / K. Itoh, M. Yahaba, A. Takahashi et al. // Int J Pharm. – 2008. –
Vol. 356. – P. 95-101.
9. Jain A. Potential of calcium pectinate beads for target specific drug release to colon / A. Jain, Y. Gupta, S.K. Jain // J Drug Targeting. – 2007. –
Vol.15, № 4. – P. 285-294.
10. Kumar P. Colon targeted drug delivery systems-an overview / P. Kumar, B. Mishra // Curr Drug Deliv. – 2008. – Vol.5, №3. – P. 186-198.
11. Lu W.Q. Influence of oxaliplatin combined with LCP on proliferation and apoptosis of colon cancer cell line HT29 / W.Q. Lu, F. Wang, H.Y. Liu //
Zhonghua Wei Chang Wai Ke Za Zhi. – 2013. – Vol.16, №1. – P. 84-88.
12. Methotrexate bearing calcium pectinate microspheres: a platform to achieve colon-specific drug release / M. Chaurasia, M.K. Chourasia,
N.K. Jain et al. // Curr Drug Deliv. – 2008. – Vol.5, №3. – P. 215-219.
13. Nakahara S. Regulation of cancer-related gene expression by galectin-3 and the molecular mechanism of its nuclear import pathway / S. Nakahara, A. Raz // Cancer Metastasis Rev. – 2007. – Vol.26. – P. 605-610.
14. Preparation and evaluation of pectin-based colon-specific pulsatile capsule in vitro and in vivo / J. Liu, L. Zhang, Y. Jia et al. // Arch Pharm
Res. – 2012. – Vol.35. – №11. – P. 1927-1934.
15. Song M. Nutrients, foods, and colorectal cancer prevention/ M. Song, W.S. Garrett, A.T Chan // Gastroenterology. – 2015. – Vol.148, N.6. –
P. 1244-1260.
16. Sigmoidal release of indomethacin from pectin matrix tablets: Effect of in situ crosslinking by calcium cations / X. Wei, N. Sun, B. Wu et al. // Int J Pharm. – 2006. – Vol.318. – P. 132-138.
17. Time-controlled oral delivery systems for colon targeting / A. Gazzaniga, A. Maroni, M.E. Sangalli et al. // Expert Opin Drug Deliv. – 2006. – Vol.3. – P. 583-597.
18. Wikiera A. Health-promoting properties of pectin / A. Wikiera, M. Irla, M. Mika // Postepy Hig Med Dosw (Online). – 2014. – Vol.68. – P. 590–
596.
19. Wong T.W. Drug release property of chitosan-pectinate beads and its changes under the influence of microwave / T.W. Wong, S. Nurjaya // Eur J Pharm Biopharm. – 2008. – Vol.69. – P. 176-188.
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Published
2019-07-03
How to Cite
Голотюк, В. В., Попович, Л. О., & Доскалюк, Б. В. (2019). PECTIN AS A UNIVERSAL REMEDY IN THE FIGHT AGAINST COLORECTAL CANCER. PRECARPATHIAN BULLETIN OF THE SHEVCHENKO SCIENTIFIC SOCIETY Pulse, (4(32), 51–59. Retrieved from https://pvntsh.nung.edu.ua/index.php/pulse/article/view/780
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КЛІНІЧНА МЕДИЦИНА
