IMMUNOLOGICAL CAUSES OF METABOLIC SYNDROME
Keywords:
metabolic syndrome; type 2 diabetes mellitus; immune system.Abstract
The article presents data from publications and the author’s personal research findings that generalize peculiarities of immunological status of patients with diabetes mellitus with syndrome of disordered metabolism. Evidence is given that immune-mediated pathological changes depend on the seriousness and durability of the disease and serve as a predictive criterion of evolving complications caused by type 2 diabetes mellitus. It is concluded that type 2 diabetes mellitus may result in two possible immune-mediated pathological disorders: variant 1 – dysfunctions of cell-mediated immunity, phagocytosis with compensatory hyperactive response of the humoral (component of the) immune system; variant 2 – cell suppression, phagocytic disorders and suppression of the humoral component which either corresponds to or proceeds the phase of suppurative complications necrotic; unfavourable for clinical treatment of type 2 diabetes mellitus. Available findings appear to be sufficient to indicate that immune therapy is not only desirable but pathogenetically proved as typically needed and promising strategies to prevent evolving diabetes-specific complications and improve the risk profile of the chronic complications as the disease progresses.
References
2. Ліпоцитокіни в ґенезі цукрового діабету 2-го типу / В.О.Малижев, Л.В.Анастасій, О.С.Ларін, М.В.Неборачко, О.Я.Гирявенко // Клінічна ендокринологія та ендокринна хірургія. – 2005. – № 1(10). – С. 3-25.
3. Маньковський Б.Н. Инсулинорезистентность: механизмы формирования и возможные пути коррекции / Б.Н.Маньковський // Рациональ-ная фармакотерапия. – 2007. – №1(02). – С. 35-38.
4. Митченко Е.И. Новый взгляд на патологию, произрастающую на общей почве: диабет и сердечно-сосудистые заболевания / Е.И.Митченко // Український медичний часопис. – 2007. – №2(58). – С. 4-13.
5. Метаболический синдрои и состояние вторичного иммунодефицита / А.М.Мкртумян, В.Д.Забелина, В.М.Земсков, Л.А.Толмакова, О.А.Ан-тонова // Проблемы эндокринологии. – 2000. – №4. – С. 10-14.
6. Паньків В.І. Цукровий діабет, переддіабет і серцево-судинні захворювання / В.І.Паньків // Практична ангіологія. – 2007. – №1(6). – С. 4-10.
7. Alberti KG, Zimmet P, Shaw J, for the IDF Epidemiology Task Force Consensus Croup. The metabolic syndrome – a new worldwide definition // Lancet. – 2005. – Vol. 366. – Р. 1059-1062.
8. Addressing the global cardiovascular risk of hypertension, dyslipidemia, diabetes mellitus, and the metabolic syndrome in the southeastern United States, part II: treatment recommendations for management of the global cardiovascular risk of hypertension, dyslipidemia, diabetes mellitus, and the metabolic syndrome / W.Bestermann, MC.Houston, J.Basile et al. // Am J Med Sciences. – 2005. – Vol. 329. – Р. 292-305.
9. Metabolic syndrome: risk factor distribution and 18-year mortality in the multiple risk factor intervention trial / L.E.Eberly, R.Prineas, J.D.Cohen, G.Vazquez, X.Zhi, J.D.Neaton, L.H.Kuller // Diabetes Care. – 2006. – Vol. 29, № 1. – Р. 123-130.
10. Development and progression of atherosclerotic disease in relation to insulin resistance and hyperinsulinemia / T.Fujiwara, S.Saitoh, S.Takagi, H.Takeuchi, T.Isobe, Y.Chiba, T.Miura, K.Shimamoto // Hypertens Res. – 2005. – Vol. 28, № 8. – Р. 665-670.
11. Addressing the global cardiovascular risk of hypertension, dyslipidemia, and insulin resistance in the southeastern United States / MC.Houston, J.Basile, WH.Bestermann et al. // Am J Med Sciences. – 2005. – Vol. 329. – Р. 276-291.
12. Guidelines 2007 for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) / G.Mancia, G.De Backer, A.Dominiczak at al. // Journal of Hypertension. – 2007. – Vol. 25. – Р. 1105-1187.
13. Two new criteria of the metabolic syndrome: prevalence and the association with brachial-ankle pulse wave velocity in Japanese male workers K.Miyaki, A.Нага, M.Naito, T.Naito, T.Nakayama // J. Occup Health . – 2006. – Vol. 48, №2. – Р. 134-140.
14. Pittas A.G. Adipocytokines and insulin resistance / A.G.Pittas, N.Joseph, A.S.Greenberg // J Clin Endocrin Metabol. – 2004. – Vol. 89. – Р. 447-452.
15. Reaven GM. Role of insulin resistance in human disease // Diabetes. – 1988. – Vol. 37, № 12. – Р. 1595–607.
16. Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC); European Association for the Study of Diabetes (EASD) Guidelines on diabetes, pre-diabetes, and cardiovascular diseases / L.Ryden, E.Standi, M.Bartnik et al. // Eur Heart J. – 2007. – Vol. 28, № 1. – Р. 88-136.
