MLS-RESISTANCE PHENOTYPES OF STAPHYLOCOCCI SKIN ISOLATES – PATHOGENS OF PYODERMA
Keywords:
staphylococci, antibiotic resistance, macrolides, pyoderma.Abstract
Article deals with MLS-resistance phenotypes of staphylococci skin isolates тpathogens of pyoderma. 50 isolates of S. аureus and 51 isolate of CNS were used to perform resistance induction testing of 14-macrolides to lincosamides and 16-macrolides. 29,7% of isolates showed two distinct induction phenotypes (labeled D and D+) linked with ribosomal resistance. 15,8% of isolates showed noninduction phenotype (Neg), contained mrsA. 20,8% of isolates demonstrated complete resistance to macrolides and lincosamides. Finally 33,7% of isolates were susceptible by disk testing to all antibiotics (S phenotype). D, D+ and R phenotype isolates showed ERY MICs >4000 µg/ml, Neg phenotype – 32-500 µg/ml, S phenotype – 2-4 µg/ml.
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