EVALUATION OF RISK IN PATIENTS WITH FAMILY HISTORY OF MULTIPLE SCLEROSIS USING THE NEW BIOMARKER
Keywords:
multiple sclerosis, disease risk, biomarker.Abstract
Multiple sclerosis (MS) is a multifactor, polygenic disease that most likely develops due to specific combination of genetic and environmental factors. Considering the role of genetic issues in MS etiology, the aim of the research was to analyze correlation between detection of the new biomarker, 48 kDa unconventional myosin 1 c isoform, in blood serum of MS patients and their family history (presence of relatives who have MS). It could help to evaluate the risk of MS in relatives of patients and therefore improve diagnostics in case they have any neurological or radiological symptoms.
References
1. Бойко А.Н. Достижения в изучении проблем рассеянного склероза (обзор) / А.Н. Бойко, Е.И. Гусев // Неврология, психиатрия. –2012. – №73(5). – С. 9-15.
2. Гусев Е.Н. Рассеянный склероз и другие демиелинизирующие заболе-вания / Е.Н. Гусев, И.А. Завалишин, А.Н. Бойко. – М.: Миклош. 2004; 1:1. – 528 с.
3. Коробко Д.С. Влияние генетических факторов на фенотипическую експрессию рассеянного склероза / Д.С. Коробко, Н.А. Малкова, Е.В. Булатова // Журнал неврологии и психиатрии. – 2013. – № 2. – С. 10-16.
4. Соколова Л.И. К вопросу о современных методах диагностики и лечения рассеянного склероза / Л.И. Соколова // Мед. вестник. – 2008. – № 1. – С. 28-32.
5. Functional roles for myosin 1c in cellular signaling pathways / L.M. Bond, H. Brandstaetter, J. Kendrick-Jones, et al. // Cell Signal. – 2013. – Vol. 5. – P. 229-235. doi:10.1016/j.cellsig.2012.09.026.
6. Microvilli structures on B lymphocytes: inducible functional domains? / G. Greicius, L. Westerberg, E.J. Davey, et al. // Int. Immunol. – 2004. – Vol. 16. – P. 353-364. doi:10.1093/intimm/dxh031.
7. Lassmann H. The immunopathology of multiple sclerosis: an overview / H. Lassmann, W. Brück, C.F. Lucchinetti // Brain Pathol. – 2007. – Vol. 17. – P. 210-8.
8. Myosin 1c participates in B cell cytoskeleton rearrangements, is recruited to the immunologic synapse, and contributes to antigen presentation / J. Maravillas-Montero, P. Gillespie, Patin~o-Lo´pez G, at al. // J Immunol. – 2011. – Vol. 187(6). – P. 30533063. doi:10.4049/jimmunol.1004018.
9. Identification of a 48 kDa form of unconventional myosin 1c in blood serum of patients with autoimmune diseases / S. Myronovkij, N. Negrych, T. Nehrych, et al. // Biochemistry and Biophysics Reports. – 2016. – Vol. 5. – P. 175-179. doi:10.1016/j.bbrep.2015.12.001.
10. The International Multiple Sclerosis Genetics Consortium (IMSGC). Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature // 2011; 476:214-9.
2. Гусев Е.Н. Рассеянный склероз и другие демиелинизирующие заболе-вания / Е.Н. Гусев, И.А. Завалишин, А.Н. Бойко. – М.: Миклош. 2004; 1:1. – 528 с.
3. Коробко Д.С. Влияние генетических факторов на фенотипическую експрессию рассеянного склероза / Д.С. Коробко, Н.А. Малкова, Е.В. Булатова // Журнал неврологии и психиатрии. – 2013. – № 2. – С. 10-16.
4. Соколова Л.И. К вопросу о современных методах диагностики и лечения рассеянного склероза / Л.И. Соколова // Мед. вестник. – 2008. – № 1. – С. 28-32.
5. Functional roles for myosin 1c in cellular signaling pathways / L.M. Bond, H. Brandstaetter, J. Kendrick-Jones, et al. // Cell Signal. – 2013. – Vol. 5. – P. 229-235. doi:10.1016/j.cellsig.2012.09.026.
6. Microvilli structures on B lymphocytes: inducible functional domains? / G. Greicius, L. Westerberg, E.J. Davey, et al. // Int. Immunol. – 2004. – Vol. 16. – P. 353-364. doi:10.1093/intimm/dxh031.
7. Lassmann H. The immunopathology of multiple sclerosis: an overview / H. Lassmann, W. Brück, C.F. Lucchinetti // Brain Pathol. – 2007. – Vol. 17. – P. 210-8.
8. Myosin 1c participates in B cell cytoskeleton rearrangements, is recruited to the immunologic synapse, and contributes to antigen presentation / J. Maravillas-Montero, P. Gillespie, Patin~o-Lo´pez G, at al. // J Immunol. – 2011. – Vol. 187(6). – P. 30533063. doi:10.4049/jimmunol.1004018.
9. Identification of a 48 kDa form of unconventional myosin 1c in blood serum of patients with autoimmune diseases / S. Myronovkij, N. Negrych, T. Nehrych, et al. // Biochemistry and Biophysics Reports. – 2016. – Vol. 5. – P. 175-179. doi:10.1016/j.bbrep.2015.12.001.
10. The International Multiple Sclerosis Genetics Consortium (IMSGC). Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature // 2011; 476:214-9.
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Published
2019-06-10
How to Cite
Негрич, Н. О. (2019). EVALUATION OF RISK IN PATIENTS WITH FAMILY HISTORY OF MULTIPLE SCLEROSIS USING THE NEW BIOMARKER. PRECARPATHIAN BULLETIN OF THE SHEVCHENKO SCIENTIFIC SOCIETY Pulse, (7(43), 51–55. Retrieved from https://pvntsh.nung.edu.ua/index.php/pulse/article/view/527
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КЛІНІЧНА МЕДИЦИНА
