ANALYSIS OF THE CONTENT OF IMMUNE COMPLEXES IN BLOOD MILK IN PATIENTS WITH MULTIPLE SCLEROSIS WITH PATHOGENETIC AND DISEASE CHARACTERISTIC THERAPY

Authors

  • M. O. Boychuk Lviv National Medical University named after Danylo Halytskyi
  • R. O. Bilyy Lviv National Medical University named after Danylo Halytskyi
  • T. I. Nehrych Lviv National Medical University named after Danylo Halytskyi

DOI:

https://doi.org/10.21802/2304-7437-2019-5(57)-114-118

Keywords:

multiple sclerosis; immunoglobulins; antibodies to the main protein of myelin; antibodies to components of secondary-necrotic cells.

Abstract

In order to determine the activity of multiple sclerosis (MS), in particular for the objective confirmation of exacerbation of the disease, it is proposed to conduct a test for analyzing the antibody to the main myelin protein (OBM) and determining the antibodies to the components of the secondary non-necrotic cells (SNEC).

References

BiermannMHC, GriffanteG, PodolskaMJ, etal. Sweet but dangerous – the role of immunoglobulin G glycosylation in autoimmunity and inflammation. Lupus. 2016;25:934–942.

Blauth K, Owens GP, Bennett JL. The Ins and Outs of B Cells in Multiple Sclerosis. Front. Immunol. 2015;6.

Breij ECW, Brink BP, Veerhuis R, et al. Homogeneity of active demyelinating lesions in established multiple sclerosis. Ann. Neurol. 2008;63:16–25.

Kao D, Lux A, Schaffert A, et al. IgG subclass and vaccination stimulus determine changes in antigen specific antibody glycosylation in mice. Eur. J. Immunol. 2017.

Lin C-W, Tsai M-H, Li S-T, et al. A common glycan structure on immunoglobulin G for enhancement of effector functions. Proc. Natl. Acad. Sci. U. S. A. 2015;112:10611–10616.

Munoz LE, Lauber K, Schiller M, et al. The role of defective clearance of apoptotic cells in systemic autoimmunity. Nat Rev Rheumatol. 2010/05/01. 2010;6:280–289.

Reusch D, Haberger M, Falck D, et al. Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles-Part 2: Mass spectrometric methods. MAbs. 2015;7:732–742.

Stümer J, Biermann MHCHC, Knopf J, et al. Altered glycan accessibility on native immunoglobulin G complexes in early rheumatoid arthritis and its changes during therapy. Clin. Exp. Immunol. 2017;189:372–382.

Sjöwall C, Zapf J, von Löhneysen S, et al. Altered glycosylation ofcomplexed native IgG molecules is associated with disease activity of systemic lupus erythematosus. Lupus. 2015;24:569–581.

Trbojević-Akmačić I, Vilaj M, Lauc G. High-throughput analysis of immunoglobulin G glycosylation. Expert Rev. Proteomics. 2016;13:523–534.

Published

2019-04-24

How to Cite

Boychuk, M. O. ., Bilyy, R. O. ., & Nehrych, T. I. . (2019). ANALYSIS OF THE CONTENT OF IMMUNE COMPLEXES IN BLOOD MILK IN PATIENTS WITH MULTIPLE SCLEROSIS WITH PATHOGENETIC AND DISEASE CHARACTERISTIC THERAPY: Array. PRECARPATHIAN BULLETIN OF THE SHEVCHENKO SCIENTIFIC SOCIETY Pulse, (5(57), 114–118. https://doi.org/10.21802/2304-7437-2019-5(57)-114-118

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