EXACERBATION OF MULTIPLE SCLEROSIS: A CLINICAL PARACLINICAL PARADOX

Authors

  • O. M. Zheshko Volyn Regional Clinical Hospital
  • O. D. Shulga Volyn Regional Clinical Hospital
  • M. I. Dubinets Volyn Regional Clinical Hospital
  • O. A. Yurko Volyn Regional Clinical Hospital
  • O. R. Lopachak Volyn Regional Clinical Hospital

DOI:

https://doi.org/10.21802/2304-7437-2019-5(57)-65-69

Keywords:

multiple sclerosis, exacerbation.

Abstract

The purpose of our work was to find out the factors that determine the treatment tactics in the presence of signs of clinical and / or radiological exacerbation in patients with remitting multiple sclerosis. 104 patients were examined, 36.25 ± 9.81 years old. It has been established that in patients with shorter duration of the disease, the incidence of clinical (p <0.001) and radiological exacerbations (p <0.001) is higher. In patients who do not receive immunomodulatory therapy (p <0.05), there are signs of both clinical and radiological exacerbation. Patients with clinical exacerbations, regardless of the presence of active foci, receive treatment with methylprednisolone in almost 95% of cases. At the same time, in the case of radiological exacerbation, treatment with methylprednisolone is prescribed in only one third of the cases.

References

Giovannoni, Gavin et al. Brain health: time matters in multiple sclerosis.Multiple Sclerosis and Related Disorders, Volume 9 (2016), S5 - S48. doi.org/10.1016/j.msard.2016.07.003.

Kurtzke J.F. Rating Neurologic Impairment in Multiple Sclerosis an Expanded Disability Status Scale (EDSS). Neurology. -1983. – 33. – P.1444–1444.

Montalban, X & Gold, Ronit & J. Thompson, A & Otero-Romero, S & P. Amato, M & Chandraratna, D & Clanet, M & Comi, G & Derfuss, Tobias & Fazekas, F & P. Hartung, H & Havrdova, Eva & Hemmer, Bernhard & Kappos, L & Liblau, R & Lubetzki, C & Marcus, E & H. Miller, D & Olsson, Tanja & Zipp, F. (2018). / ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis. // European Journal of Neurology. 25. 10.1111/ene.13536.

Polman, C. H. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria [Text] / C. H. Polman, S. C. Reingold, B. Banwell, M. Clanet, J. A. Cohen, M. Filippi et. al // Annals of Neurology. – 2011. – Vol. 69, Issue 2. – P. 292–302. doi: 10.1002/ana.22366

Thompson, Alan J., et al. / "Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria." // The Lancet Neurology (2017). - P. 162-173.

Published

2019-04-24

How to Cite

Zheshko, O. M. ., Shulga, O. D. ., Dubinets, M. I. ., Yurko, O. A. ., & Lopachak, O. R. . (2019). EXACERBATION OF MULTIPLE SCLEROSIS: A CLINICAL PARACLINICAL PARADOX. PRECARPATHIAN BULLETIN OF THE SHEVCHENKO SCIENTIFIC SOCIETY Pulse, (5(57), 65–69. https://doi.org/10.21802/2304-7437-2019-5(57)-65-69