@article{I.V. Koshel_Ya.R. Maksymenko_2022, title={ASSESSMENT OF THE INFLUENCE OF PREOPERATIVE ADMINISTRATION OF AMINOCAPROIC ACID ON THE COURSE OF THE POSTOPERATIVE PERIOD IN PATIENTS WITH NASAL POLYPOSIS}, url={https://pvntsh.nung.edu.ua/index.php/pulse/article/view/1860}, DOI={10.21802/2304-7437-2022-18(66)-43-52}, abstractNote={<p><em>Chronic rhinosinusitis with nasal polyposis (CRSwNP) by the dominant endotype includes eosinophilic one, which is the most severe option. Patients, as</em></p> <p> </p> <p><em>a</em> <em>rule,</em> <em>have</em> <em>a</em> <em>more</em> <em>severe</em> <em>clinical</em> <em>course,</em> <em>polyps</em> <em>grow quickly and often recur. The main method of operative treatment is the functional endoscopic endonasal surgery. Peculiarities of the CRSwNP endotype justify the use of aminocaproic acid (ACA) for the preoperative preparation. To assess the effect of preoperative administration of aminocaproic acid on the course of the early postoperative period in comparison with the patients receiving standard therapy for CRSwNP according to the clinical recommendations. The study included 120 outpatients, divided into two groups: main (n - 60) and control (n - 60) ones. The patients were prescribed basic treatment (irrigation therapy with saline solutions and mometasone furoate), and the main group additionally received ACA. Patients who had to be treated surgically, were performed FESS. In order to determine the peculiarities of the postoperative period, there were selected 20 patients – 10 from each group. An analysis of nasal breathing and transport function of the ciliated epithelium of the nasal cavity was performed.</em></p> <p><em>The</em> <em>use</em> <em>of</em> <em>aminocaproic</em> <em>acid</em> <em>in</em> <em>CRSwNP</em> <em>facilitates</em> <em>a</em> <em>significant</em> <em>reduction</em> <em>in</em> <em>the</em> <em>number</em> <em>of</em> <em>operated</em> <em>patients:</em> <em>the</em> <em>necessity</em> <em>for</em> <em>surgical</em> <em>intervention</em> <em>in</em> <em>the main group was in 56.7% of patients and in 81.7% of patients in the control group. The results of the analysis of the dynamics of nasal breathing restoration and mucociliary clearance showed that the seventh day of the postoperative period ended with almost complete restoration of nasal breathing and the transport function of the ciliated epithelium of the nasal cavity of patients of the experimental and control groups. Differences in the course of the postoperative period are not statistically significant.</em></p> <p><em>The use of ACA in addition to the basic therapy in patients with CRSwNP reduces the necessity for surgical treatment at 25%.</em></p> <p><em>There was noted no impact of the additional prescription of ACA in the preoperative period on the course of the postoperative period in the operated patients.</em></p> <p><strong><em>Key words: </em></strong><em>Polypous rhinosinusitis, aminocaproic acid, surgical treatment.</em></p>}, number={18 (66)}, journal={PRECARPATHIAN BULLETIN OF THE SHEVCHENKO SCIENTIFIC SOCIETY Pulse}, author={I.V. Koshel and Ya.R. Maksymenko}, year={2022}, month={Dec.}, pages={43–52} }